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KMID : 0381120070290040521
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Genes and Genomics
2007 Volume.29 No. 4 p.521 ~ p.527
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Heterogeneous Upregulation of Lysosomal Genes in Human Fibroblasts and Cancer Cells Undergoing Senescence
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Park Ji-Hoon
Lee Hye-Won
DiMaio Daniel
Hwang Eun-Seong
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Abstract
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Cellular programs that control lysosome activity and biosynthesis are largely unexplored. We found that the lysosome number and the expression of lysosomal genes increase substantially in normal fibroblasts undergoing replicative or induced senescence and in HeLa cervical carcinoma cells undergoing induced senescence. This suggests that cellular programs that control lysosomogenesis are activated in senescence regardless of the cell type and the nature of the senescence stimulus. However, there was a substantial discordance in the extent of induction among different lysosomal genes and in different types of senescence, suggesting heterogeneity in regulatory mechanisms within the family of lysosomal genes as well as in the senescence programs themselves.
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KEYWORD
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lysosome, senescence, cathepsin A, lysotracker, Lamp2a
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